Teosyal RHA 3 is a soft tissue filler made of cross-linked hyaluronic acid and non-modified hyaluronic acid gel. The gel is transparent, extremely durable, and very elastic. Each package contains 23mg/mL of synthetic hyaluronic acid and 3 mg/m of fast-acting anesthetic lidocaine, supplied in a 1mL syringe. Each box of Teosyal RHA 3 comes with 2 preloaded syringes and 2 sterile 27G ½” disposable needles, 4 traceability labels, as well as an instructional leaflet. The packaging is fragile and must be stored away from direct sunlight at temperatures ranging from 2ºC to 25ºC. This aesthetic solution is formulated by Teoxane Laboratories in Switzerland and is part of their Teosyal RHA (Resilient Hyaluronic Acid) product range.


Teosyal RHA 3 is indicated for the treatment of deep-set wrinkles and creases on extremely mobile areas of the face such as nasogenian furrows and vertical lip lines. Sunken areas can also be restored with added volume, while skin depressions caused by scars can be filled in using this dermal filler. Furthermore, thin and defined lips can be made plump and sensuous.


As we age, the skin is not as efficient as it used to be at producing new healthy cells and repairing the damage. During the aging process, vital proteins that maintain the skin’s distinct elasticity and hydration, like collagen and hyaluronic acid, reduce in number and productivity. Because of this, creases begin to appear in areas where repeated facial expressions occur, like the forehead and cheeks. Additionally, skin becomes dehydrated and scars are not repaired as quickly as in younger skin. In some cases, aging is accompanied by unintended facial fat loss or redistribution, leading to a gaunt complexion. On top of all this, external aggressors like excessive sunlight and pollution introduce lots of harmful free radicals into the skin, making skin issues even more noticeable. 

Teosyal RHA 3 is formulated using Resilient Hyaluronic Acid Technology to combine cross-linked hyaluronic acid and non-modified hyaluronic acid into 1 gel. Cross-linked hyaluronic acid strands are able to resist biodegradation for a longer time while non-modified hyaluronic acid delivers much-needed elasticity. Once injected, the implant closely mimics the hyaluronic acid that is naturally present in the skin and adapts to extensive facial movements, allowing facial creases to be erased with a natural-looking finish. Lidocaine is also present in the filler solution in order to provide comfortable, pain-free treatment.


Though this is a minimally invasive treatment, it is still a medical procedure that can only be performed by licensed medical professionals specializing in aesthetic treatments. Treatment with this aesthetic filler typically involves the following steps:

  • Initial Consultation:

Preliminary consultation sessions are very important in order to understand a patient’s medical history. Analyze your patient’s medical records (e.g. existing diseases, drugs and/or supplements taken) to determine their suitability to receive soft tissue filler injections. If they do take any medications and/or supplements that interfere with normal blood clotting process (e.g. aspirin, warfarin, NSAIDs, high doses of vitamin E, fish oil, ginkgo Biloba), then advise them to stop taking those agents the week before treatment. The consultation session is also the time for you to explain the foreseeable effects of treatment, both desirable and unintended. Once your client is deemed suitable and ready, set the date for treatment.

  • Prior to Injection:

During this time, it is important to ensure that the filler is still within its shelf life and that the original packaging is still intact. Please discard any filler that is past its expiry date or that has spoiled packaging. As part of the aseptic procedure, thoroughly clean and disinfect the proposed area for correction.

  • During Injection:

Assemble the medical device by aseptically attaching and securing the needle provided to the preloaded syringe. Inject the filler gel slowly into the deep dermis layer using a linear threading injection technique. Too deep of an injection into the subcutaneous layer may not provide adequate correction, and injecting too superficially might result in unintended discoloration of the skin. Nevertheless, do not overcorrect any area, and cap the total amount of filler gel used to less than 3mL per session. Do not inject into superficial lines, blood vessels, or eyelids. After treating the desired areas, gently massage the sites to encourage seamless gel integration into the facial contours.

  • After Injection:

Once the treatment is complete discard any unused gel and used medical supplies, including syringes and needles. Please do not sterilize the syringe, as it is only intended for single use. The aftercare methods are as follows.

  1. Keep the area free of makeup and maintain skin hygiene as per usual for up to 12 hours after injection.
  2. Avoid alcoholic beverages and intensive sports like jogging and tennis for up to 3 days after injection.
  3. Postpone any dental treatments and avoid exposing the treated areas to sunlight and extreme temperature like sauna and frost for up to 15 days following injection. 

 Refer to device instruction leaflet for more information on injection directions and precautions.


Clinical trials have found that most of the products in this Teosyal range can last for about 6 to 9 months, after which the patient can receive additional injections to maintain the desired effects. Teosyal RHA 3 is biodegradable and is broken down and absorbed into the surrounding tissues.


The hyaluronic acid in Teosyal RHA 3 is manufactured via a process of bacterial fermentation and is purified to be pyrogen-free. Despite being synthetic, the hyaluronic acid is just as efficient as the naturally-occurring stores found in the skin, making this filler extremely biocompatible. The entire manufacturing process is conducted in sterile environment to minimize the risk of introducing harmful contaminants. This ensures that there is very little chance of inducing immunogenic responses in users. Despite its enhanced safety profile, this filler is still contraindicated in some clients:

Clients who are allergic/hypersensitive to hyaluronan;

Clients who are allergic/hypersensitive to lidocaine or amide local anaesthetics;

Clients with a history of allergic attacks;

Clients with autoimmune/liver/heart diseases;

Clients with skin diseases (e.g. acne, hives, wounds, herpes) on proposed treatment site;

Clients who are pregnant or breastfeeding;

Clients who are less than 18 years of age.

Refer to device instruction leaflet for more information on contraindications and warnings.


Your patients may exhibit some localized inflammatory responses such as redness, swelling, and pain at the injection sites. Furthermore, reactions like blood clots, itching, pus, induration, tissue death, and gel displacement may occur, though these are rare. Patients must seek immediate medical care if any of the symptoms last for more than a week. Hypersensitive responses or full-blown anaphylactic reactions are very serious and must be treated immediately at the nearest hospital. 


Teosyal RHA 3 is a soft tissue filler consisting of cross-linked hyaluronic acid and non-modified hyaluronic acid gel. The resulting gel is transparent and very viscoelastic and can resist degradation for an extended period of time. The active ingredients are 23mg/mL of non-animal hyaluronic acid and 3mg/ml of the fast-acting anesthetic lidocaine, reconstituted in a phosphate buffer solution with a pH of 7.3. This aesthetic solution is perfect for correcting deep facial wrinkles as well as for augmenting lips and restoring volume to gaunt areas of the face.

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